RASGRP3 Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 6q12-q13
Cellular Component:  cytoplasm; guanyl-nucleotide exchange factor complex; perinuclear region of cytoplasm
Molecular Function:  calcium ion binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; kinase binding; metal ion binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process:  positive regulation of GTPase activity; Ras protein signal transduction; regulation of GTPase activity
Reference #:  NP_001101479 (RefSeq)
Alt. Names/Synonyms: RAS guanyl releasing protein 3; RAS guanyl releasing protein 3 (calcium and DAG-regulated); RAS, guanyl releasing protein 3; Rasgrp3
Gene Symbols: Rasgrp3
Molecular weight: 68,292 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept