G3BP-2 iso2 Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; RNA-binding
Chromosomal Location of Human Ortholog: 5|5 E2
Cellular Component:  cytoplasmic stress granule; cytosol; ribonucleoprotein complex
Molecular Function:  mRNA binding; nucleic acid binding; RNA binding
Biological Process:  mRNA transport; positive regulation of stress granule assembly; protein homooligomerization; small GTPase mediated signal transduction; stress granule assembly
Reference #:  P97379-2 (UniProtKB)
Alt. Names/Synonyms: AA409541; E430034L04Rik; G3BP; G3BP-2; G3BP-2 iso2; G3bp2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; KIAA0660; mKIAA0660; Ras GTPase-activating protein-binding protein 2; Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2; Ras-GTPase-activating protein (GAP<120>) SH3-domain binding protein 2
Gene Symbols: G3bp2
Molecular weight: 50,784 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
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G3BP-2 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene