TRIM24 an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphorylation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Tumor suppressor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q33-q34
Cellular Component:  cytosol; nuclear euchromatin; nucleoplasm; nucleus; perichromatin fibrils
Molecular Function:  chromatin binding; estrogen response element binding; lysine-acetylated histone binding; nuclear receptor binding; p53 binding; protein binding; protein kinase activity; signaling receptor binding; transcription coactivator activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  calcium ion homeostasis; cellular response to estrogen stimulus; negative regulation of cell proliferation; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein catabolic process; protein ubiquitination; regulation of apoptotic process; regulation of protein stability; regulation of signal transduction by p53 class mediator; regulation of vitamin D receptor signaling pathway; transcription by RNA polymerase II
Disease: Thyroid Carcinoma, Papillary
Reference #:  O15164 (UniProtKB)
Alt. Names/Synonyms: hTIF1; PTC6; RING finger protein 82; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; TRIM24; tripartite motif protein 24; tripartite motif-containing 24; Tripartite motif-containing protein 24
Gene Symbols: TRIM24
Molecular weight: 116,831 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein