TRIM24 Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Tumor suppressor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q33-q34
Cellular Component:  cytosol; nuclear euchromatin; nucleoplasm; nucleus; perichromatin fibrils
Molecular Function:  chromatin binding; estrogen response element binding; lysine-acetylated histone binding; nuclear receptor binding; p53 binding; protein binding; protein kinase activity; signaling receptor binding; transcription coactivator activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  calcium ion homeostasis; cellular response to estrogen stimulus; negative regulation of cell proliferation; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein catabolic process; protein ubiquitination; regulation of apoptotic process; regulation of protein stability; regulation of signal transduction by p53 class mediator; regulation of vitamin D receptor signaling pathway; transcription by RNA polymerase II
Disease: Thyroid Carcinoma, Papillary
Reference #:  O15164 (UniProtKB)
Alt. Names/Synonyms: hTIF1; PTC6; RING finger protein 82; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; TRIM24; tripartite motif protein 24; tripartite motif-containing 24; Tripartite motif-containing protein 24
Gene Symbols: TRIM24
Molecular weight: 116,831 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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