RIOK3 identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
Protein type: ATYPICAL group; EC; Kinase, protein; Protein kinase, atypical; RIO family; RIO3 subfamily
Chromosomal Location of Human Ortholog: 18 A1|18 6.15 cM
Cellular Component:  cytoplasm; cytosol; preribosome, small subunit precursor
Molecular Function:  ATP binding; caspase binding; kinase activity; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to dsDNA; cellular response to dsRNA; cellular response to virus; defense response to virus; immune system process; innate immune response; maturation of SSU-rRNA; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of MDA-5 signaling pathway; negative regulation of protein homooligomerization; phosphorylation; positive regulation of innate immune response; positive regulation of interferon-beta production; ribosome biogenesis
Reference #:  Q9DBU3 (UniProtKB)
Alt. Names/Synonyms: 1200013N13Rik; D18Ertd331e; E130306C24Rik; RIO kinase 3; RIO kinase 3 (yeast); Riok3; Serine/threonine-protein kinase RIO3; Sudd; sudD, suppressor of bimD6 homolog
Gene Symbols: Riok3
Molecular weight: 58,704 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene