RIOK3 Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; RIO family; RIO3 subfamily
Chromosomal Location of mouse Ortholog: 18 A1|18 6.15 cM
Cellular Component:  cytoplasm; cytosol; preribosome, small subunit precursor
Molecular Function:  ATP binding; caspase binding; kinase activity; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to dsDNA; cellular response to dsRNA; cellular response to virus; defense response to virus; immune system process; innate immune response; maturation of SSU-rRNA; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of MDA-5 signaling pathway; negative regulation of protein homooligomerization; phosphorylation; positive regulation of innate immune response; positive regulation of interferon-beta production; ribosome biogenesis
Reference #:  Q9DBU3 (UniProtKB)
Alt. Names/Synonyms: 1200013N13Rik; D18Ertd331; D18Ertd331e; E130306C24Rik; RIO kinase 3; RIO kinase 3 (yeast); Riok3; Serine/threonine-protein kinase RIO3; Sud; Sudd; sudD, suppressor of bimD6 homolog
Gene Symbols: Riok3
Molecular weight: 58,704 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene