SFRS15 Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 16|16 C3.3
Cellular Component:  nucleoplasm
Molecular Function:  protein C-terminus binding
Biological Process:  mRNA processing
Reference #:  Q7TSH6 (UniProtKB)
Alt. Names/Synonyms: AA517739; CTD-binding SR-like protein RA4; Scaf4; Sfrs15; Splicing factor, arginine/serine-rich 15; SR-related CTD-associated factor 4; Sra4
Gene Symbols: Scaf4
Molecular weight: 129,056 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene