LYL1 A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component: 
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity
Biological Process:  B cell differentiation; blood vessel maturation; definitive hemopoiesis; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
Reference #:  P12980 (UniProtKB)
Alt. Names/Synonyms: BHLHA18; Class A basic helix-loop-helix protein 18; LYL1; lymphoblastic leukemia derived sequence 1; Lymphoblastic leukemia-derived sequence 1; Protein lyl-1
Gene Symbols: LYL1
Molecular weight: 29,938 Da
Basal Isoelectric point: 10.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene