|
RIOK2
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: ATYPICAL group; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; RIO family; RIO2 subfamily |
| Chromosomal Location of mouse Ortholog: 17|17 A3.1 |
|
Cellular Component:
cytoplasm; cytosol; nucleus; preribosome, small subunit precursor
|
|
Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
|
|
Biological Process:
maturation of SSU-rRNA; phosphorylation; positive regulation of ribosomal small subunit export from nucleus; positive regulation of rRNA processing; protein autophosphorylation; protein phosphorylation; regulation of mitotic metaphase/anaphase transition; ribosomal small subunit biogenesis; ribosome biogenesis
|
|
Reference #:
Q9CQS5
(UniProtKB)
|
|
Alt. Names/Synonyms: 2010110K24Rik; 2410085M17Rik; RIO kinase 2; RIO kinase 2 (yeast); Riok2; Serine/threonine-protein kinase RIO2
|
|
Gene Symbols: Riok2
|
|
Molecular weight:
62,490 Da
|
|
Basal Isoelectric point:
6
Predict pI for various phosphorylation states
|
