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BCL2A1
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11. Belongs to the Bcl-2 family. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 15q25.1 |
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Cellular Component:
cytoplasm; cytosol; mitochondrial outer membrane
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Molecular Function:
protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of apoptotic process
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Reference #:
Q16548
(UniProtKB)
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Alt. Names/Synonyms: ACC-1; ACC-2; ACC1; ACC2; B2LA1; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2 related protein A1; Bcl2-L-5; BCL2-related protein A1; BCL2A1; BCL2L5; BFL1; GRS; HBPA1; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
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Gene Symbols: BCL2A1
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Molecular weight:
20,132 Da
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Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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