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RIOK2
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; RIO family; RIO2 subfamily |
| Chromosomal Location of human Ortholog: 5q15 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; preribosome, small subunit precursor
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
cell cycle; maturation of SSU-rRNA; positive regulation of ribosomal small subunit export from nucleus; positive regulation of rRNA processing; protein autophosphorylation; regulation of mitotic metaphase/anaphase transition; ribosomal small subunit biogenesis
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Reference #:
Q9BVS4
(UniProtKB)
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Alt. Names/Synonyms: FLJ11159; RIO kinase 2; RIO kinase 2 (yeast); RIO2; RIOK2; Serine/threonine-protein kinase RIO2
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Gene Symbols: RIOK2
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Molecular weight:
63,283 Da
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Basal Isoelectric point:
5.66
Predict pI for various phosphorylation states
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