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RIOK1
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; RIO family; RIO1 subfamily |
| Chromosomal Location of mouse Ortholog: 13|13 A3.3 |
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Cellular Component:
cytoplasm; cytosol; methyltransferase complex; preribosome, small subunit precursor
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Molecular Function:
ATP binding; hydrolase activity; kinase activity; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
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Biological Process:
maturation of SSU-rRNA; phosphorylation; positive regulation of rRNA processing; ribosomal small subunit biogenesis; ribosome biogenesis
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Reference #:
Q922Q2
(UniProtKB)
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Alt. Names/Synonyms: 3110046C13Rik; 5430416A05Rik; Ad034; AL033302; MGC7300; RIO kinase 1; RIO kinase 1 (yeast); Riok1; Serine/threonine-protein kinase RIO1
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Gene Symbols: Riok1
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Molecular weight:
64,910 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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