BACE2
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. Belongs to the peptidase A1 family. Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.23.45; Membrane protein, integral; Protease |
Chromosomal Location of rat Ortholog: 11q12 |
Cellular Component:
dense core granule; endoplasmic reticulum; endosome; Golgi apparatus; melanosome membrane; plasma membrane; trans-Golgi network
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Molecular Function:
aspartic-type endopeptidase activity; peptidase activity
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Biological Process:
amyloid-beta metabolic process; astrocyte activation; glucose homeostasis; melanosome organization; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; protein processing; signaling receptor ligand precursor processing
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Reference #:
Q6IE75
(UniProtKB)
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Alt. Names/Synonyms: Bace2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
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Gene Symbols: Bace2
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Molecular weight:
55,858 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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