APOA2
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Belongs to the apolipoprotein A2 family. Plasma; synthesized in the liver and intestine. Note: This description may include information from UniProtKB.
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Protein type: Endoplasmic reticulum; Lipid-binding; Secreted; Secreted, signal peptide |
Chromosomal Location of rat Ortholog: 13q24 |
Cellular Component:
chylomicron; extracellular space; high-density lipoprotein particle; spherical high-density lipoprotein particle; very-low-density lipoprotein particle
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Molecular Function:
apolipoprotein receptor binding; cholesterol binding; cholesterol transfer activity; enzyme binding; heat shock protein binding; high-density lipoprotein particle binding; high-density lipoprotein particle receptor binding; lipase inhibitor activity; lipid binding; lipid transporter activity; phosphatidylcholine binding; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipid binding; protein heterodimerization activity; protein homodimerization activity; signaling receptor binding
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Biological Process:
animal organ regeneration; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; diacylglycerol catabolic process; high-density lipoprotein particle assembly; high-density lipoprotein particle clearance; high-density lipoprotein particle remodeling; intermembrane lipid transfer; lipid transport; lipoprotein metabolic process; low-density lipoprotein particle remodeling; negative regulation of cholesterol import; negative regulation of cholesterol transport; negative regulation of cholesterol transporter activity; negative regulation of cytokine production involved in immune response; negative regulation of lipase activity; negative regulation of lipid catabolic process; negative regulation of very-low-density lipoprotein particle remodeling; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; phospholipid catabolic process; phospholipid efflux; positive regulation of CoA-transferase activity; positive regulation of interleukin-8 production; positive regulation of lipid catabolic process; positive regulation of phagocytosis; protein oxidation; protein stabilization; regulation of intestinal cholesterol absorption; regulation of protein stability; response to estrogen; response to glucocorticoid; response to glucose; response to xenobiotic stimulus; reverse cholesterol transport; triglyceride-rich lipoprotein particle remodeling
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Reference #:
P04638
(UniProtKB)
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Alt. Names/Synonyms: Apo-AII; ApoA-II; Apoa2; APOAII; Apolipoprotein A-II; Apolipoprotein A2
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Gene Symbols: Apoa2
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Molecular weight:
11,439 Da
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Basal Isoelectric point:
6.22
Predict pI for various phosphorylation states
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