TRRAP Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Kinase, protein; Nuclear receptor co-regulator; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; TRRAP subfamily; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component:  Golgi apparatus; NuA4 histone acetyltransferase complex; nucleoplasm; nucleus; PCAF complex; STAGA complex; Swr1 complex; transcription factor TFTC complex
Molecular Function:  protein binding; transcription coregulator activity
Biological Process:  beta-catenin-TCF complex assembly; histone acetylation; histone deubiquitination; histone H2A acetylation; histone H4 acetylation; protein deubiquitination
Disease: Developmental Delay With Or Without Dysmorphic Facies And Autism
Reference #:  Q9Y4A5 (UniProtKB)
Alt. Names/Synonyms: 350/400 kDa PCAF-associated factor; FLJ10671; PAF350/400; PAF400; STAF40; TR-AP; Tra1; Tra1 homolog; Transformation/transcription domain-associated protein; TRRAP
Gene Symbols: TRRAP
Molecular weight: 437,600 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein