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SMG1
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. Belongs to the PI3/PI4-kinase family. Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.1; Kinase, protein; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; SMG1 subfamily |
| Chromosomal Location of human Ortholog: 16p12.3 |
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Cellular Component:
chromatoid body; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; telomeric DNA binding
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Biological Process:
DNA damage response; DNA repair; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; peptidyl-serine phosphorylation; phosphatidylinositol phosphate biosynthetic process; protein autophosphorylation; protein phosphorylation; regulation of telomere maintenance
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Reference #:
Q96Q15
(UniProtKB)
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Alt. Names/Synonyms: 61E3.4; ATX; hSMG-1; KIAA0421; Lambda-interacting protein; Lambda/iota protein kinase C-interacting protein; LIP; phosphatidylinositol 3-kinase-related kinase; phosphatidylinositol 3-kinase-related protein kinase; PI-3-kinase-related kinase SMG-1; Serine/threonine-protein kinase SMG1; SMG-1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase; SMG1; SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans); SMG1 nonsense mediated mRNA decay associated PI3K related kinase; SMG1 phosphatidylinositol 3-kinase-related kinase
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Gene Symbols: SMG1
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Molecular weight:
410,501 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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