PDHK1 Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Belongs to the PDK/BCKDK protein kinase family. Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 2.7.11.2; Kinase, protein; Mitochondrial; PDHK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of human Ortholog: 2q31.1
Cellular Component:  mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; nucleus
Molecular Function:  ATP binding; protein binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity
Biological Process:  cell proliferation; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process
Reference #:  Q15118 (UniProtKB)
Alt. Names/Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; PDHK1; PDK1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase 1; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
Gene Symbols: PDK1
Molecular weight: 49,244 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PDHK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene