PAFAH1B2 Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 3.1.1.47; Lipase; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 8q22
Cellular Component:  1-alkyl-2-acetylglycerophosphocholine esterase complex; cytoplasm; cytosol; fibrillar center; nucleolus; plasma membrane
Molecular Function:  1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding; platelet-activating factor acetyltransferase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding
Biological Process:  lipid catabolic process; positive regulation of macroautophagy; spermatogenesis
Reference #:  O35264 (UniProtKB)
Alt. Names/Synonyms: MGC93124; PA1B2; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; Pafah1b2; Pafahb; Platelet-activating factor acetylhydrolase alpha 2 subunit; platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2); Platelet-activating factor acetylhydrolase IB subunit alpha2; Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit; platelet-activating factor acetylhydrolase, isoform Ib, subunit 2
Gene Symbols: Pafah1b2
Molecular weight: 25,581 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
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PAFAH1B2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene