LIN7C Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 3q34
Cellular Component:  basolateral plasma membrane; bicellular tight junction; cell-cell junction; cytoplasm; glutamatergic synapse; MPP7-DLG1-LIN7 complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; presynapse; synapse
Molecular Function:  cytoskeletal protein binding; L27 domain binding; PDZ domain binding; protein domain specific binding
Biological Process:  exocytosis; maintenance of epithelial cell apical/basal polarity; morphogenesis of an epithelial sheet; neurotransmitter secretion; protein localization to basolateral plasma membrane; protein transport
Reference #:  Q792I0 (UniProtKB)
Alt. Names/Synonyms: lin 7 homolog C; lin-7 homolog C (C. elegans); lin-7-C; Lin-7C; Lin7c; MALS-3; Mals3; Mammalian lin-seven protein 3; Protein lin-7 homolog C; Veli-3; veli-3 protein; Veli3; Vertebrate lin-7 homolog 3
Gene Symbols: Lin7c
Molecular weight: 21,834 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene