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ACP6
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Belongs to the histidine acid phosphatase family. Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; Mitochondrial; Motility/polarity/chemotaxis; Phosphatase (non-protein); Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1q21.2 |
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Cellular Component:
cytoplasm; mitochondrial matrix; mitochondrion
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Molecular Function:
acid phosphatase activity; lysophosphatidic acid phosphatase activity; phosphatase activity
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Biological Process:
dephosphorylation; hematopoietic progenitor cell differentiation; lysobisphosphatidic acid metabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process
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Reference #:
Q9NPH0
(UniProtKB)
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Alt. Names/Synonyms: Acid phosphatase 6, lysophosphatidic; acid phosphatase like 1; Acid phosphatase-like protein 1; ACP6; ACPL1; LPAP; Lysophosphatidic acid phosphatase type 6; PACPL1; PPA6
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Gene Symbols: ACP6
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Molecular weight:
48,886 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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