ACP6 Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Belongs to the histidine acid phosphatase family. Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC; Mitochondrial; Motility/polarity/chemotaxis; Phosphatase (non-protein); Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 1q21.2
Cellular Component:  cytoplasm; mitochondrial matrix; mitochondrion
Molecular Function:  acid phosphatase activity; lysophosphatidic acid phosphatase activity; phosphatase activity
Biological Process:  dephosphorylation; hematopoietic progenitor cell differentiation; lysobisphosphatidic acid metabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process
Reference #:  Q9NPH0 (UniProtKB)
Alt. Names/Synonyms: Acid phosphatase 6, lysophosphatidic; acid phosphatase like 1; Acid phosphatase-like protein 1; ACP6; ACPL1; LPAP; Lysophosphatidic acid phosphatase type 6; PACPL1; PPA6
Gene Symbols: ACP6
Molecular weight: 48,886 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene