AKR1D1 Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). Belongs to the aldo/keto reductase family. Highly expressed in liver. Expressed in testis and weakly in colon. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase
Chromosomal Location of human Ortholog: 7q33
Cellular Component:  cytosol
Molecular Function:  aldo-keto reductase (NADP) activity; delta4-3-oxosteroid 5beta-reductase activity; steroid binding
Biological Process:  androgen metabolic process; bile acid biosynthetic process; bile acid catabolic process; C21-steroid hormone metabolic process; cholesterol catabolic process; digestion; oxidation-reduction process
Disease: Bile Acid Synthesis Defect, Congenital, 2
Reference #:  P51857 (UniProtKB)
Alt. Names/Synonyms: 3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; AK1D1; AKR1D1; Aldo-keto reductase family 1 member D1; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); CBAS2; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase; SRD5B1; steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1)
Gene Symbols: AKR1D1
Molecular weight: 37,377 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene