BCKDK Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. Belongs to the PDK/BCKDK protein kinase family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 2.7.11.4; Kinase, protein; Mitochondrial; PDHK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of mouse Ortholog: 7|7 F3
Cellular Component:  mitochondrial alpha-ketoglutarate dehydrogenase complex; mitochondrion
Molecular Function:  [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; transferase activity, transferring phosphorus-containing groups
Biological Process:  branched-chain amino acid catabolic process; phosphorylation; protein phosphorylation
Reference #:  O55028 (UniProtKB)
Alt. Names/Synonyms: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; AI327402; BCKD; BCKD-ki; BCKD-kinase; BCKDHKIN; Bckdk; branched chain ketoacid dehydrogenase kinase; Branched-chain alpha-ketoacid dehydrogenase kinase; OTTMUSP00000030822
Gene Symbols: Bckdk
Molecular weight: 46,588 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Select Structure to View Below

BCKDK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene