PDHK3 Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. Belongs to the PDK/BCKDK protein kinase family. Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 2.7.11.2; Kinase, protein; Mitochondrial; PDHK family; Protein kinase, atypical
Chromosomal Location of Human Ortholog: X|X C3
Cellular Component:  mitochondrion; nucleolus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity
Biological Process:  carbohydrate metabolic process; cellular response to fatty acid; cellular response to glucose stimulus; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; peptidyl-serine phosphorylation; peroxisome proliferator activated receptor signaling pathway; phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process; regulation of reactive oxygen species metabolic process
Reference #:  Q922H2 (UniProtKB)
Alt. Names/Synonyms: 2610001M10Rik; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; AI035637; MGC6383; OTTMUSP00000019497; Pdk3; pyruvate dehydrogenase kinase 3; Pyruvate dehydrogenase kinase isoform 3; pyruvate dehydrogenase kinase, isoenzyme 3
Gene Symbols: Pdk3
Molecular weight: 47,923 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

PDHK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene