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NDUFS1
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Belongs to the complex I 75 kDa subunit family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase |
| Chromosomal Location of rat Ortholog: 9q32 |
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Cellular Component:
mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; mitochondrion; respirasome
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Molecular Function:
2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron transfer activity; metal ion binding; NADH dehydrogenase (ubiquinone) activity
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Biological Process:
apoptotic mitochondrial changes; ATP metabolic process; ATP synthesis coupled electron transport; cellular respiration; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; reactive oxygen species metabolic process; regulation of mitochondrial membrane potential
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Reference #:
Q66HF1
(UniProtKB)
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Alt. Names/Synonyms: MGC93795; NADH dehydrogenase (ubiquinone) Fe-S protein 1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Ndufs1; NDUS1
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Gene Symbols: Ndufs1
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Molecular weight:
79,412 Da
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Basal Isoelectric point:
5.65
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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