PDHK4 Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. Belongs to the PDK/BCKDK protein kinase family. Ubiquitous; highest levels of expression in heart and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; Kinase, protein; Mitochondrial; PDHK family; PDHK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of mouse Ortholog: 6 A1|6 2.06 cM
Cellular Component:  mitochondrion
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine/tyrosine kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity
Biological Process:  carbohydrate metabolic process; cellular response to fatty acid; cellular response to starvation; glucose homeostasis; glucose metabolic process; insulin receptor signaling pathway; negative regulation of anoikis; phosphorylation; protein phosphorylation; reactive oxygen species metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of bone resorption; regulation of cellular ketone metabolic process; regulation of fatty acid biosynthetic process; regulation of fatty acid oxidation; regulation of glucose metabolic process; regulation of pH; response to starvation
Reference #:  O70571 (UniProtKB)
Alt. Names/Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; AV005916; PDHK4; Pdk4; pyruvate dehydrogenase kinase 4; Pyruvate dehydrogenase kinase isoform 4; pyruvate dehydrogenase kinase, isoenzyme 4
Gene Symbols: Pdk4
Molecular weight: 46,596 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein