PCOLCE Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q12
Cellular Component:  extracellular space
Molecular Function:  collagen binding; heparin binding; peptidase activator activity
Biological Process:  cellular response to leukemia inhibitory factor; positive regulation of peptidase activity; proteolysis
Reference #:  O08628 (UniProtKB)
Alt. Names/Synonyms: MGC105446; PCOC1; Pcolce; PCPE; PCPE-1; Pcpe1; procollagen C-endopeptidase enhancer; Procollagen C-endopeptidase enhancer 1; procollagen C-endopeptidase enhancer protein; Procollagen C-proteinase enhancer 1; procollagen C-proteinase enhancer protein; Procollagen COOH-terminal proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer
Gene Symbols: Pcolce
Molecular weight: 50,185 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene