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PRPS1
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine |
| Chromosomal Location of rat Ortholog: Xq32 |
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Cellular Component:
cytoplasm; cytosol; protein-containing complex; ribose phosphate diphosphokinase complex
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Molecular Function:
ADP binding; AMP binding; ATP binding; carbohydrate binding; GDP binding; identical protein binding; kinase activity; magnesium ion binding; protein binding; protein homodimerization activity; ribose phosphate diphosphokinase activity
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Biological Process:
5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; animal organ regeneration; hypoxanthine biosynthetic process; nervous system development; nucleotide biosynthetic process; pentose-phosphate shunt; phosphorylation; purine nucleobase metabolic process; purine nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; urate biosynthetic process
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Reference #:
P60892
(UniProtKB)
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Alt. Names/Synonyms: Phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase 1; phosphoribosyl pyrophosphate synthetase I; Prps1; PRS-I; Ribose-phosphate pyrophosphokinase 1
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Gene Symbols: Prps1
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Molecular weight:
34,834 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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