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PDHK2
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Belongs to the PDK/BCKDK protein kinase family. Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.2; Kinase, protein; Mitochondrial; PDHK family; PDHK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical |
| Chromosomal Location of rat Ortholog: 10q26 |
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Cellular Component:
cytosol; mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleoplasm; pyruvate dehydrogenase complex
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Molecular Function:
ATP binding; identical protein binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity
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Biological Process:
cellular response to nutrient; cellular response to reactive oxygen species; glucose homeostasis; glucose metabolic process; insulin receptor signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of calcium-mediated signaling; regulation of cellular ketone metabolic process; regulation of gluconeogenesis; regulation of glucose metabolic process; regulation of pH
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Reference #:
Q64536
(UniProtKB)
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Alt. Names/Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; PDHK2; PDK P45; Pdk2; pyruvate dehydrogenase 2; pyruvate dehydrogenase kinase 2 subunit p45 (PDK2); Pyruvate dehydrogenase kinase isoform 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2
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Gene Symbols: Pdk2
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Molecular weight:
46,106 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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