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MYST3
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Belongs to the MYST (SAS/MOZ) family. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.48; Nucleolus; Oncoprotein |
| Chromosomal Location of Human Ortholog: 16q12.5 |
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Cellular Component:
cytosol; histone acetyltransferase complex; MOZ/MORF histone acetyltransferase complex; nuclear chromatin; nuclear speck; nucleolus; nucleosome; nucleus; PML body
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Molecular Function:
acetyltransferase activity; chromatin binding; DNA binding; H4 histone acetyltransferase activity; histone acetyltransferase activity; histone binding; metal ion binding; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding
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Biological Process:
animal organ development; aorta morphogenesis; cellular senescence; embryonic hemopoiesis; face morphogenesis; heart morphogenesis; histone acetylation; histone H3 acetylation; histone H4 acetylation; myeloid cell differentiation; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription, DNA-templated; nucleosome assembly; positive regulation of gene expression; positive regulation of nucleic acid-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein acetylation; regulation of transcription, DNA-templated; somatic stem cell population maintenance
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Reference #:
Q5TKR9
(UniProtKB)
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Alt. Names/Synonyms: Histone acetyltransferase KAT6A; Histone acetyltransferase MYST3; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein; Moz; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST protein 3; MYST-3; Myst3; Runxbp2; Znf220
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Gene Symbols: Myst3
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Molecular weight:
223,331 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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