MYST3 Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Belongs to the MYST (SAS/MOZ) family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Nucleolus; Oncoprotein
Chromosomal Location of Human Ortholog: 16q12.5
Cellular Component:  cytosol; histone acetyltransferase complex; MOZ/MORF histone acetyltransferase complex; nuclear chromatin; nuclear speck; nucleolus; nucleosome; nucleus; PML body
Molecular Function:  acetyltransferase activity; chromatin binding; DNA binding; H4 histone acetyltransferase activity; histone acetyltransferase activity; histone binding; metal ion binding; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding
Biological Process:  animal organ development; aorta morphogenesis; cellular senescence; embryonic hemopoiesis; face morphogenesis; heart morphogenesis; histone acetylation; histone H3 acetylation; histone H4 acetylation; myeloid cell differentiation; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription, DNA-templated; nucleosome assembly; positive regulation of gene expression; positive regulation of nucleic acid-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein acetylation; regulation of transcription, DNA-templated; somatic stem cell population maintenance
Reference #:  Q5TKR9 (UniProtKB)
Alt. Names/Synonyms: Histone acetyltransferase KAT6A; Histone acetyltransferase MYST3; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein; Moz; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST protein 3; MYST-3; Myst3; Runxbp2; Znf220
Gene Symbols: Myst3
Molecular weight: 223,331 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene