G11 Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors. Belongs to the STK19 family. Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; G11 family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  nuclear speck; nucleus
Molecular Function:  ATP binding; protein serine/threonine kinase activity; Ras GTPase binding
Biological Process:  positive regulation of Ras protein signal transduction; protein phosphorylation
Reference #:  P49842 (UniProtKB)
Alt. Names/Synonyms: D6S60; D6S60E; G11; HLA-RP1; MGC117388; MHC class III HLA-RP1; Nuclear serine/threonine protein kinase; Protein G11; Protein RP1; RP1; serine/threonine kinase 19; Serine/threonine-protein kinase 19; STK19
Gene Symbols: STK19
Molecular weight: 40,916 Da
Basal Isoelectric point: 9.8  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein