BRD4 an atypical protein kinase of the Brd family. Contains a double bromodomain. Binds to chromatin and regulates cell cycle progression at multiple stages. Associates with chromosomes during mitosis. The cognate gene is the chromosome 19 target of translocation t(15;19)(q13;p13.1), resulting in the BRD4-NUT oncogene identified in a lethal carcinoma of young people. Binds to papillomavirus E2 protein and is required for its transforming ability. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BRD family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component:  condensed nuclear chromosome; cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin binding; enzyme binding; lysine-acetylated histone binding; P-TEFb complex binding; p53 binding; protein binding; RNA polymerase II C-terminal domain binding; RNA polymerase II CTD heptapeptide repeat kinase activity; transcription regulator recruiting activity
Biological Process:  cellular response to DNA damage stimulus; chromatin organization; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of histone H3-K36 trimethylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of inflammatory response; regulation of phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription involved in G1/S transition of mitotic cell cycle; viral process
Reference #:  O60885 (UniProtKB)
Alt. Names/Synonyms: BRD4; bromodomain containing 4; bromodomain-containing 4; Bromodomain-containing protein 4; CAP; chromosome-associated protein; HUNK1; HUNKI; MCAP; Protein HUNK1
Gene Symbols: BRD4
Molecular weight: 152,219 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BRD4

Protein Structure Not Found.


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2I8N
2LSP
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