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APCL
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. Belongs to the adenomatous polyposis coli (APC) family. Widely expressed (at protein level). Specifically expressed in the CNS. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, peripheral |
| Chromosomal Location of mouse Ortholog: 10|10 C1 |
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Cellular Component:
actin filament; beta-catenin destruction complex; catenin complex; cytoplasm; cytoplasmic microtubule; cytosol; filamentous actin; Golgi apparatus; intercellular bridge; lamellipodium membrane; microtubule cytoskeleton; midbody; perinuclear region of cytoplasm; postsynapse
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Molecular Function:
beta-catenin binding; gamma-catenin binding; microtubule binding
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Biological Process:
activation of GTPase activity; cell fate specification; cell migration; microtubule cytoskeleton organization; negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; nervous system development; pattern specification process; positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of cell differentiation
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Reference #:
Q9Z1K7
(UniProtKB)
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Alt. Names/Synonyms: adenomatosis polyposis coli 2; Adenomatous polyposis coli protein 2; AI852447; APC regulator of WNT signaling pathway 2; Apc2; APCL; R75424
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Gene Symbols: Apc2
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Molecular weight:
243,139 Da
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Basal Isoelectric point:
9.12
Predict pI for various phosphorylation states
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