APCL Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. Belongs to the adenomatous polyposis coli (APC) family. Widely expressed (at protein level). Specifically expressed in the CNS. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  actin filament; catenin complex; cytoplasm; cytosol; Golgi apparatus; intercellular bridge; lamellipodium membrane; microtubule cytoskeleton; midbody; perinuclear region of cytoplasm; postsynapse
Molecular Function:  beta-catenin binding; microtubule binding; protein binding
Biological Process:  activation of GTPase activity; microtubule cytoskeleton organization; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 10; Sotos Syndrome 3
Reference #:  O95996 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; APC2; APCL
Gene Symbols: APC2
Molecular weight: 243,949 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB