BRD2 May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BRD family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of mouse Ortholog: 17 B1|17 17.98 cM
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  chromatin binding; lysine-acetylated histone binding
Biological Process:  chromatin organization; nucleosome assembly; regulation of transcription by RNA polymerase II
Reference #:  Q7JJ13 (UniProtKB)
Alt. Names/Synonyms: AW228947; Brd2; bromodomain containing 2; Bromodomain-containing protein 2; D17H6S113; D17H6S113E; female sterile homeotic-related gene 1; Female sterile homeotic-related protein 1; Frg-; Frg-1; Fsr; Fsrg-1; Fsrg1; Kiaa4005; mKIAA4005; NAT; Protein RING3; Ring3; Rnf3
Gene Symbols: Brd2
Molecular weight: 88,067 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene