DYNC2H1
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells. Belongs to the dynein heavy chain family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 11q22.3 |
Cellular Component:
9+2 motile cilium; apical part of cell; axoneme; ciliary tip; cilium; cytoplasmic dynein complex; Golgi apparatus; microtubule; plasma membrane
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Molecular Function:
ATP binding; cytoskeletal motor activity; dynein intermediate chain binding; dynein light intermediate chain binding; minus-end-directed microtubule motor activity; protein binding
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Biological Process:
cilium assembly; cilium movement involved in cell motility; coronary vasculature development; determination of left/right symmetry; dorsal/ventral pattern formation; embryonic limb morphogenesis; forebrain development; Golgi organization; intraciliary retrograde transport; kidney development; non-motile cilium assembly; positive regulation of smoothened signaling pathway; protein localization to cilium; protein processing; spinal cord motor neuron differentiation
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Disease: Short-rib Thoracic Dysplasia 3 With Or Without Polydactyly
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Reference #:
Q8NCM8
(UniProtKB)
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Alt. Names/Synonyms: ATD3; Cytoplasmic dynein 2 heavy chain; Cytoplasmic dynein 2 heavy chain 1; DHC1B; DHC2; DNCH2; DYH1B; DYHC2; DYNC2H1; dynein cytoplasmic 2 heavy chain 1; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11; Dynein heavy chain isotype 1B; dynein heavy chain, isotype 1B; dynein, cytoplasmic 2, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 2; FLJ11756; hDHC11; KIAA1997; SRPS2B; SRTD3
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Gene Symbols: DYNC2H1
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Molecular weight:
492,622 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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