DTNA
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Belongs to the dystrophin family. Dystrobrevin subfamily. Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 18 A2|18 12.08 cM |
Cellular Component:
axon; cell junction; cell projection; cytoplasm; dystrobrevin complex; extrinsic component of cytoplasmic side of plasma membrane; intermediate filament cytoskeleton; membrane; nucleoplasm; plasma membrane; protein-containing complex; sarcolemma; synapse
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Molecular Function:
metal ion binding; PDZ domain binding; phosphatase binding; protein binding; zinc ion binding
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Biological Process:
synaptic signaling
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Reference #:
Q9D2N4
(UniProtKB)
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Alt. Names/Synonyms: 2210407P21Rik; a-DB-; a-DB-1; A0; adbn; Alpha-dystrobrevin; Dtn; DTN-A; Dtna; Dystrobrevin alpha; Gm19389
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Gene Symbols: Dtna
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Molecular weight:
84,067 Da
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Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
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