BRD2 May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BRD family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of human Ortholog: 6p21.32
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  chromatin binding; lysine-acetylated histone binding; protein binding; protein serine/threonine kinase activity
Biological Process:  neural tube closure; nucleosome assembly; protein phosphorylation; regulation of transcription by RNA polymerase II; spermatogenesis
Reference #:  P25440 (UniProtKB)
Alt. Names/Synonyms: BRD2; BRD2 intronic transcript 1; BRD2-IT1; bromodomain containing 2; bromodomain-containing 2; Bromodomain-containing protein 2; D6S113E; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; FSRG1; KIAA9001; NAT; O27.1.1; Really interesting new gene 3 protein; RING3; RNF3
Gene Symbols: BRD2
Molecular weight: 88,061 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRD2
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein