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GDF2
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. Belongs to the TGF-beta family. Detected in blood plasma (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 10q11.22 |
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Cellular Component:
cell; extracellular region
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Molecular Function:
growth factor activity; protein binding
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Biological Process:
activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; branching involved in blood vessel morphogenesis; cartilage development; cellular iron ion homeostasis; cellular response to BMP stimulus; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of DNA biosynthetic process; negative regulation of DNA replication; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; ossification; osteoblast differentiation; pathway-restricted SMAD protein phosphorylation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cartilage development; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of signaling receptor activity; vasculogenesis
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Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5
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Reference #:
Q9UK05
(UniProtKB)
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Alt. Names/Synonyms: BMP-9; BMP9; Bone morphogenetic protein 9; GDF-2; GDF2; growth differentiation factor 2; Growth/differentiation factor 2; HHT5
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Gene Symbols: GDF2
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Molecular weight:
47,320 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Wnt/ß-Catenin Signaling
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