GDF2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. Belongs to the TGF-beta family. Detected in blood plasma (at protein level). Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q11.22
Cellular Component:  cell; extracellular region
Molecular Function:  growth factor activity; protein binding
Biological Process:  activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; branching involved in blood vessel morphogenesis; cartilage development; cellular iron ion homeostasis; cellular response to BMP stimulus; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of DNA biosynthetic process; negative regulation of DNA replication; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; ossification; osteoblast differentiation; pathway-restricted SMAD protein phosphorylation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cartilage development; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of signaling receptor activity; vasculogenesis
Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5
Reference #:  Q9UK05 (UniProtKB)
Alt. Names/Synonyms: BMP-9; BMP9; Bone morphogenetic protein 9; GDF-2; GDF2; growth differentiation factor 2; Growth/differentiation factor 2; HHT5
Gene Symbols: GDF2
Molecular weight: 47,320 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

GDF2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene