ChaK2 Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; ChaK subfamily; Channel, cation; EC; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component:  apical plasma membrane; brush border membrane; integral component of membrane; plasma membrane
Molecular Function:  ATP binding; calcium channel activity; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  calcium ion transmembrane transport; protein phosphorylation; protein tetramerization; response to toxic substance
Disease: Hypomagnesemia 1, Intestinal
Reference #:  Q9BX84 (UniProtKB)
Alt. Names/Synonyms: CHAK2; Channel kinase 2; HMGX; HOMG; HOMG1; HSH; Melastatin-related TRP cation channel 6; Transient receptor potential cation channel subfamily M member 6; transient receptor potential cation channel, subfamily M, member 6; TRPM6
Gene Symbols: TRPM6
Molecular weight: 231,708 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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