CUL4B Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis. Belongs to the cullin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: Xq24
Cellular Component:  Cul4-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; cytosol; nucleoplasm
Molecular Function:  protein binding
Biological Process:  DNA damage response, detection of DNA damage; G1/S transition of mitotic cell cycle; global genome nucleotide-excision repair; histone H2A monoubiquitination; neuron projection development; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of protein catabolic process; post-translational protein modification; proteasomal protein catabolic process; protein ubiquitination; ribosome biogenesis; transcription-coupled nucleotide-excision repair; UV-damage excision repair
Disease: Mental Retardation, X-linked, With Short Stature, Hypogonadism, And Abnormal Gait
Reference #:  Q13620 (UniProtKB)
Alt. Names/Synonyms: CUL-4B; CUL4B; cullin 4B; Cullin-4B; KIAA0695; MRXHF2; MRXS15; MRXSC; SFM2
Gene Symbols: CUL4B
Molecular weight: 103,982 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
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CUL4B

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein