ChaK1 is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; ChaK subfamily; Channel, cation; EC; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, atypical
Chromosomal Location of Human Ortholog: 2|2 F1
Cellular Component:  cytoplasm; integral component of membrane; membrane; neuron projection; neuronal cell body; plasma membrane; ruffle; synaptic vesicle membrane; varicosity
Molecular Function:  actin binding; ATP binding; calcium channel activity; cation channel activity; ion channel activity; kinase activity; metal ion binding; myosin binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actomyosin structure organization; calcium ion transmembrane transport; calcium ion transport; calcium-dependent cell-matrix adhesion; cation transport; cellular magnesium ion homeostasis; ion transport; memory; necroptotic process; phosphorylation; positive regulation of apoptotic process; programmed cell death; protein autophosphorylation; protein phosphorylation; protein tetramerization; transmembrane transport
Reference #:  Q923J1 (UniProtKB)
Alt. Names/Synonyms: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; Chak; CHAK1; Channel-kinase 1; Long transient receptor potential channel 7; Ltpr7; LTrpC-7; LTrpC7; OTTMUSP00000017028; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; Transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; TRP-PLIK; Trpm7; TRPPLIK
Gene Symbols: Trpm7
Molecular weight: 212,399 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene