DNASE1L3 Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation. Belongs to the DNase I family. Liver and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Calcium-binding; Deoxyribonuclease; EC 3.1.21.-; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 3p14.3
Cellular Component:  endoplasmic reticulum; extracellular region; nucleus
Molecular Function:  calcium ion binding; deoxyribonuclease activity; deoxyribonuclease I activity; DNA binding; protein binding
Biological Process:  apoptotic DNA fragmentation; DNA catabolic process; DNA catabolic process, endonucleolytic; DNA metabolic process; neutrophil activation involved in immune response; nucleic acid phosphodiester bond hydrolysis; programmed cell death involved in cell development; regulation of acute inflammatory response; regulation of neutrophil mediated cytotoxicity
Disease: Systemic Lupus Erythematosus 16
Reference #:  Q13609 (UniProtKB)
Alt. Names/Synonyms: deoxyribonuclease 1 like 3; Deoxyribonuclease gamma; Deoxyribonuclease I-like 3; deoxyribonuclease I-like III; DHP2; DNAS1L3; DNase gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I-like 3; DNASE1L3; DNSL3; Liver and spleen DNase; LS-DNase; LSD; SLEB16
Gene Symbols: DNASE1L3
Molecular weight: 35,504 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene