ChaK1 Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; ChaK subfamily; Channel, cation; EC; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, atypical
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  integral component of membrane; plasma membrane; ruffle
Molecular Function:  actin binding; ATP binding; calcium channel activity; metal ion binding; myosin binding; protein serine/threonine kinase activity
Biological Process:  actomyosin structure organization; calcium ion transmembrane transport; calcium-dependent cell-matrix adhesion; cellular magnesium ion homeostasis; necroptotic process; protein autophosphorylation; protein tetramerization
Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1
Reference #:  Q96QT4 (UniProtKB)
Alt. Names/Synonyms: CHAK; CHAK1; Channel-kinase 1; FLJ20117; FLJ25718; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; LTRPC7; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; TRP-PLIK; TRPM7
Gene Symbols: TRPM7
Molecular weight: 212,697 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
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