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SLCO2B1
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. Belongs to the organo anion transporter (TC 2.A.60) family. Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 11q13.4 |
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Cellular Component:
apical plasma membrane; basal plasma membrane; basolateral plasma membrane; plasma membrane
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Molecular Function:
organic anion transmembrane transporter activity; prostaglandin transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; transmembrane transporter activity
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Biological Process:
heme catabolic process; monoatomic ion transport; organic anion transport; prostaglandin transport; sodium-independent organic anion transport; transmembrane transport; transport across blood-brain barrier; xenobiotic metabolic process
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Reference #:
O94956
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686E0517; KIAA0880; OATP-B; OATP-RP2; OATP2B1; OATPB; OATPRP2; Organic anion transporter B; Organic anion transporter polypeptide-related protein 2; SLC21A9; SLCO2B1; SO2B1; solute carrier family 21 (organic anion transporter), member 9; Solute carrier family 21 member 9; Solute carrier organic anion transporter family member 2B1; solute carrier organic anion transporter family, member 2B1
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Gene Symbols: SLCO2B1
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Molecular weight:
76,699 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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