Claudin-8 Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Expressed in the epididymis, mainly in the caput segment. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component:  apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; integral component of membrane
Molecular Function:  identical protein binding; protein binding; structural molecule activity
Biological Process:  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Reference #:  P56748 (UniProtKB)
Alt. Names/Synonyms: claudin 8; Claudin-8; claudin8; CLD8; CLDN8; epididymis secretory protein Li 79; HEL-S-79
Gene Symbols: CLDN8
Molecular weight: 24,845 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB