GTF2F1 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the TFIIF alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 2.7.11.1; GTF2F1 family; Kinase, protein; Transcription initiation complex
Chromosomal Location of Human Ortholog: 9q12
Cellular Component:  cell junction; intracellular membrane-bound organelle; nucleus; protein complex; transcription factor TFIID complex
Molecular Function:  DNA binding; phosphatase activator activity; protein binding; protein domain specific binding; protein phosphatase binding; RNA binding; transcription factor binding
Biological Process:  positive regulation of catalytic activity; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; response to virus; transcription initiation from RNA polymerase II promoter
Reference #:  Q6AY96 (UniProtKB)
Alt. Names/Synonyms: General transcription factor IIF subunit 1; general transcription factor IIF, polypeptide 1; general transcription factor IIF, polypeptide 1, 74kDa; Gtf2f1; MGC94148; T2FA; TFIIF-alpha; Transcription initiation factor IIF subunit alpha
Gene Symbols: Gtf2f1
Molecular weight: 57,181 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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GTF2F1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene