HDGF Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. Belongs to the HDGF family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Transcription regulation
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cytoplasm; extracellular space; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function:  DNA-binding transcription repressor activity, RNA polymerase II-specific; growth factor activity; heparin binding; nucleotide binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription corepressor activity; transcription corepressor binding
Biological Process:  cellular process; cellular response to interleukin-7; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein localization to nucleus; regulation of signaling receptor activity
Reference #:  Q8VHK7 (UniProtKB)
Alt. Names/Synonyms: HDGF; Hepatoma-derived growth factor
Gene Symbols: Hdgf
Molecular weight: 26,488 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene