SPPL2B Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis. Belongs to the peptidase A22B family. Expressed predominantly in adrenal cortex and mammary gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of mouse Ortholog: 10|10 C1
Cellular Component:  actin cytoskeleton; centrosome; endosome; endosome membrane; Golgi apparatus; Golgi-associated vesicle membrane; integral component of cytoplasmic side of endoplasmic reticulum membrane; integral component of lumenal side of endoplasmic reticulum membrane; integral component of membrane; lysosomal membrane; lysosome; membrane; nucleoplasm; plasma membrane
Molecular Function:  aspartic endopeptidase activity, intramembrane cleaving; aspartic-type endopeptidase activity; hydrolase activity; peptidase activity; protein homodimerization activity
Biological Process:  membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; proteolysis; regulation of immune response
Reference #:  Q3TD49 (UniProtKB)
Alt. Names/Synonyms: 3110056O03Rik; AW550292; protein SPP-like 2B; protein SPPL2b; PSL1; RIKEN cDNA 3110056O03 gene; signal peptide peptidase like 2B; Signal peptide peptidase-like 2B; SPP-like 2B; SPP2B; SPPL2b
Gene Symbols: Sppl2b
Molecular weight: 63,824 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene