SLC35A1 Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 6q15
Cellular Component:  Golgi apparatus; Golgi membrane; membrane; plasma membrane
Molecular Function:  antiporter activity; CMP-N-acetylneuraminate transmembrane transporter activity; protein binding; UDP-galactose transmembrane transporter activity
Biological Process:  carbohydrate metabolic process; carbohydrate transport; CMP-N-acetylneuraminate transmembrane transport; protein modification process; UDP-galactose transmembrane transport
Disease: Congenital Disorder Of Glycosylation, Type Iif
Reference #:  P78382 (UniProtKB)
Alt. Names/Synonyms: CDG2F; CMP-SA-Tr; CMP-Sia-Tr; CMP-sialic acid transporter; CMPST; CST; FLJ76955; hCST; mutated CMP-sialic acid transporter A1; S35A1; SLC35A1; solute carrier family 35 (CMP-sialic acid transporter), member 1; solute carrier family 35 (CMP-sialic acid transporter), member A1; solute carrier family 35 (UDP-galactose transporter), member 1; Solute carrier family 35 member A1
Gene Symbols: SLC35A1
Molecular weight: 36,779 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene