|
SLC35A1
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 6q15 |
|
Cellular Component:
Golgi apparatus; Golgi membrane; membrane; plasma membrane
|
|
Molecular Function:
antiporter activity; CMP-N-acetylneuraminate transmembrane transporter activity; protein binding; UDP-galactose transmembrane transporter activity
|
|
Biological Process:
carbohydrate metabolic process; carbohydrate transport; CMP-N-acetylneuraminate transmembrane transport; protein modification process; UDP-galactose transmembrane transport
|
|
Disease: Congenital Disorder Of Glycosylation, Type Iif
|
|
Reference #:
P78382
(UniProtKB)
|
|
Alt. Names/Synonyms: CDG2F; CMP-SA-Tr; CMP-Sia-Tr; CMP-sialic acid transporter; CMPST; CST; FLJ76955; hCST; mutated CMP-sialic acid transporter A1; S35A1; SLC35A1; solute carrier family 35 (CMP-sialic acid transporter), member 1; solute carrier family 35 (CMP-sialic acid transporter), member A1; solute carrier family 35 (UDP-galactose transporter), member 1; Solute carrier family 35 member A1
|
|
Gene Symbols: SLC35A1
|
|
Molecular weight:
36,779 Da
|
|
Basal Isoelectric point:
9.11
Predict pI for various phosphorylation states
|
