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FIP1L1
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. Belongs to the FIP1 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; RNA-binding |
| Chromosomal Location of rat Ortholog: 14p11 |
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Cellular Component:
mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus
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Molecular Function:
RNA binding
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Biological Process:
mRNA processing
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Reference #:
Q5U317
(UniProtKB)
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Alt. Names/Synonyms: FIP1; FIP1 like 1 (S. cerevisiae); FIP1-like 1 protein; Fip1l1; MGC93674; Pre-mRNA 3'-end-processing factor FIP1
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Gene Symbols: Fip1l1
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Molecular weight:
60,188 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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