MED31 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 31 family. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  nucleoplasm; ubiquitin ligase complex
Molecular Function:  protein binding; ubiquitin protein ligase activity
Biological Process:  limb development; negative regulation of fibroblast proliferation; positive regulation of nucleic acid-templated transcription; protein ubiquitination; transcription initiation from RNA polymerase II promoter
Reference #:  Q9Y3C7 (UniProtKB)
Alt. Names/Synonyms: 3110004H13Rik; CGI-125; FLJ27436; FLJ36714; hSOH1; MED31; Mediator complex subunit 31; Mediator complex subunit SOH1; Mediator of RNA polymerase II transcription subunit 31; mediator of RNA polymerase II transcription, subunit 31 homolog; SOH1
Gene Symbols: MED31
Molecular weight: 15,805 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below

MED31

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB